Sex hormone-sensitive gene complex linked to premenstrual mood disorder

(NIH/National Institute of Mental Health) Researchers have discovered molecular mechanisms that may underlie a woman's susceptibility to disabling irritability, sadness, and anxiety in the days leading up to her menstrual period. In women with premenstrual dysphoric disorder (PMDD), they found dysregulated expression in a sex hormone-responsive gene complex which adds to evidence that PMDD is a disorder of cellular response to estrogen and progesterone.